Although quitting smoking during the 1st trimester of pregnancy reduces the risk of low birth weight, it isn’t enough to protect the unborn child from being born shorter with smaller brain size, a new study from the University of Eastern Finland shows. The study looked at 1.4 million mother-child pairs in Finland, analyzing the effect of maternal smoking on newborns’ body size and body proportions when the mother had smoked only during the 1st trimester as opposed to continued smoking. The findings were published in BMJ Open yesterday.
Smoking during pregnancy increases the risk for adverse pregnancy outcomes not only in the neonatal period but also much later, possibly even in late adulthood. Tobacco smoke contains thousands of chemicals, which can cross the placenta and enter fetal circulation. Among them, nicotine has a multitude of adverse effects on the development of organs, including the brain. Other well-known toxic chemicals in tobacco smoke include carbon monoxide, which can interfere with the unborn child’s oxygen supply.
“Smoking during pregnancy is relatively common. In this study, 84.5% were non-smokers and 3.5% quit smoking during the 1st trimester, but 12% continued to smoke after the 1st trimester,” Researcher Isabell Rumrich from the University of Eastern Finland says.
The study showed that maternal smoking is associated with a stronger reduction in body length and head circumference than in birth weight, leading to changed body proportions. The effects on body proportions of having quit smoking during the 1st trimester or having continued smoking after the 1st trimester were similar, stressing the importance of early pregnancy as a sensitive exposure window. Among the newborns exposed to maternal smoking only during the 1st trimester, all three measurements of body size (birth weight, body length and head circumference) showed signs of growth restriction. Also, their body proportions were abnormal.
Furthermore, the study suggests a limited potential to repair fetal damage induced in early pregnancy. Maternal smoking can affect cell proliferation during organogenesis in early prenatal development. Insults during this period have been shown to persist throughout life.
“The most important finding of our study is that although quitting smoking in the 1st trimester reduces the risk of low birth weight, brain size and body length in relation to body weight seem not to catch up. This stresses the importance of quitting smoking already before pregnancy since even smoking only during early pregnancy can have devastating effects on the long term health of the unborn child,” Rumrich notes.
Rumrich I, Vähäkangas K, Viluksela M, et al. Effects of maternal smoking on body size and proportions at birth: a register-based cohort study of 1.4 million births. BMJ Open 2020;10:e033465. doi: 10.1136/bmjopen-2019-033465
Source: University of Eastern Finland